We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polymorphisms of xenobiotic‐metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan.
- Authors
Kamiza, Abram Bunya; You, Jeng‐Fu; Wang, Wen‐Chang; Tang, Reiping; Chang, Chun‐Yu; Chien, Huei‐Tzu; Lai, Chih‐Hsiung; Chiu, Li‐Ling; Lo, Tsai‐Ping; Hung, Kuan‐Yi; Hsiung, Chao A.; Yeh, Chih‐Ching
- Abstract
Cytochrome P450 (<italic>CYP</italic>), glutathione‐S‐transferase (<italic>GST</italic>), and N‐acetyltransferase (<italic>NAT</italic>) are crucial for metabolism and clearance of xenobiotics. This study investigated whether <italic>CYP</italic>, <italic>GST</italic>, and <italic>NAT</italic> single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The interaction between these SNPs and cigarette smoking or meat consumption was also explored. We identified 270 patients with Lynch syndrome from the Taiwan Hereditary Nonpolyposis Colorectal Cancer Consortium. A weighted Cox proportional hazard model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs). The GSTA1 rs3957356 TT (HR = 5.36, 95% CI = 2.39–12.0) and CYP1B1 rs1056836 CC (HR = 7.24, 95% CI = 3.51–14.9) were significantly associated with CRC risk when compared to wild‐type CC and GG genotypes, respectively. However, the <italic>CYP1A1</italic> rs4646903 CC genotype significantly reduced the risk of CRC (HR = 0.33, 95% CI = 0.12–0.89) when compared to TT genotype. Moreover, significant interactions were observed between <italic>NAT1</italic> acetylation and <italic>CYP1B1</italic> rs1056827 and meat consumption.Our results suggest that xenobiotic‐metabolizing SNPs are not only associated with CRC risk in patients with Lynch syndrome in Taiwan but also interact with meat consumption to modify the disease risk. Environ. Mol. Mutagen. 59:69–78, 2018. © 2017 Wiley Periodicals, Inc.
- Subjects
TAIWAN; GENETIC polymorphisms; XENOBIOTICS; HEREDITARY nonpolyposis colorectal cancer; CANCER risk factors; CYTOCHROME P-450; PUBLIC health
- Publication
Environmental & Molecular Mutagenesis, 2018, Vol 59, Issue 1, p69
- ISSN
0893-6692
- Publication type
Article
- DOI
10.1002/em.22113