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- Title
Development and external validation of a nomogram to predict high-grade papillary bladder cancer before first-time transurethral resection of the bladder tumor.
- Authors
Wakai, Ken; Utsumi, Takanobu; Yoneda, Kei; Oka, Ryo; Endo, Takumi; Yano, Masashi; Fujimura, Masaaki; Kamiya, Naoto; Sekita, Nobuyuki; Mikami, Kazuo; Sugano, Isamu; Hiruta, Nobuyuki; Suzuki, Hiroyoshi
- Abstract
Background: The aim of this study was to identify the clinical predictors related to the risk of high-grade papillary bladder cancer before first-time transurethral resection of a bladder tumor (TUR-Bt), and to develop and validate a nomogram predicting the risk of high-grade papillary bladder cancer.Methods: A retrospective clinical study of consecutive patients who underwent first-time TUR-Bt for papillary bladder cancer was performed. Medical records were reviewed uniformly, and the following data were collected: age, sex, episodes of urinary symptoms, tumor size, number of tumors, location of the largest tumor (lateral walls, base, posterior wall, dome, and anterior wall), tumor appearance (papillary or non-papillary, pedunculated or sessile), and urinary cytology. Data from 254 patients (Group A) were used for the development of a nomogram, while data from 170 patients (Group B) were used for its external validation.Results: High-grade papillary bladder cancer was pathologically diagnosed in 51.6 and 74.6% of Group A and Group B patients, respectively. Based on univariable analyses in Group A, macrohematuria, tumor size, multiple tumors, appearance, and positive urinary cytology were selected as variables to incorporate into a nomogram. The AUC value was 0.81 for the internal validation (Group A), and 0.78 for the external validation (Group B). This novel nomogram can predict high-grade papillary bladder cancer accurately.Conclusions: The present nomogram can help clinicians calculate the probability in patients with bladder cancer before TUR-Bt and decide on earlier intervention and priorities for the treatment of patients diagnosed with bladder cancer.
- Subjects
BLADDER cancer treatment; TRANSURETHRAL prostatectomy; TRANSITIONAL cell carcinoma; ONCOLOGY; CANCER patients
- Publication
International Journal of Clinical Oncology, 2018, Vol 23, Issue 5, p957
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-018-1299-y