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- Title
Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.
- Authors
Tanaka, Sébastien; De Tymowski, Christian; Tran-Dinh, Alexy; Meilhac, Olivier; Lortat-Jacob, Brice; Zappella, Nathalie; Jean-Baptiste, Sylvain; Robert, Tiphaine; Goletto, Tiphaine; Godet, Cendrine; Castier, Yves; Mal, Hervé; Mordant, Pierre; Atchade, Enora; Messika, Jonathan; Montravers, Philippe
- Abstract
High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12-1.62] mmol/L vs. HDL-C = 1.55 [1.22-1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations =1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary.
- Subjects
LUNG transplantation; HIGH density lipoproteins; HDL cholesterol; CHRONIC obstructive pulmonary disease; PULMONARY fibrosis
- Publication
Transplant International, 2023, Vol 36, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2023.10841