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- Title
Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla.
- Authors
Simon B; Schmidt S; Lukas C; Gieseke J; Träber F; Knol DL; Willinek WA; Geurts JJ; Schild HH; Barkhof F; Wattjes MP; Simon, Birgit; Schmidt, Stephan; Lukas, Carsten; Gieseke, Jürgen; Träber, Frank; Knol, Dirk L; Willinek, Winfried A; Geurts, Jeroen J G; Schild, Hans H
- Abstract
<bold>Objective: </bold>To investigate the impact of a higher magnetic field strength of 3 Tesla (T) on the detection rate of cortical lesions in multiple sclerosis (MS) patients, in particular using a dedicated double inversion recovery (DIR) pulse sequence.<bold>Methods: </bold>Thirty-four patients with clinically isolated syndromes or definite MS were included. All patients underwent magnetic resonance imaging (MRI) at 1.5 T and 3 T, including T2-weighted turbo spin echo (TSE), fluid-attenuated inversion recovery (FLAIR) and DIR sequences. All images were analysed for focal lesions categorised according to their anatomical location.<bold>Results: </bold>The total number of detected lesions was higher at 3 T across all pulse sequences. We observed significantly higher numbers of lesions involving the cortex at 3 T using a DIR sequence. DIR at 3 T showed 192% more pure intracortical (p < 0.001) and 30% more mixed grey matter-white matter lesions (p = 0.008). No significant increase in cortical lesions could be detected on the FLAIR and T2-weighted images. Using the T2-weighted and FLAIR sequences, significantly more lesions could be detected at 3 T in the infratentorial, periventricular and juxtacortical white matter.<bold>Conclusion: </bold>DIR brain MR imaging at 3 T substantially improves the sensitivity of the detection of cortical lesions compared with the standard magnetic field strength of 1.5 T.
- Publication
European Radiology, 2010, Vol 20, Issue 7, p1675
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-009-1705-y