We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Expression of myeloperoxidase in swine influenza virus (SIV)-infected neutrophils in lungs from pigs experimentally infected with SIV subtype H1N2.
- Authors
Kim, Bongtae; Shin, Jeoung; Han, Kiwon; Seo, Hwi; Oh, Yeonsu; Kang, Ikjae; Park, Changhoon; Lee, Bog-Hieu; Jang, Jin; Kim, Sung-Hoon; Chae, Chanhee
- Abstract
The expression of myeloperoxidase (MPO) was examined in the swine influenza virus (SIV)-infected neutrophils in the lungs of pigs experimentally infected with swine influenza virus (SIV) subtype H1N2 by immunohistochemistry. Five pigs each from the infected and non-infected group were euthanized 1, 3, 5, 7, and 10 days post-inoculation (dpi). Immunohistochemical reactivity was mainly seen in neutrophils. The score for pulmonary histopathological lesions correlated with the score for MPO immunohistochemical reactivity ( r = 0.962, P < 0.01). In addition, the score for in situ hybridization of SIV nucleic acid correlated with the score for MPO immunohistochemical reactivity ( r = 0.976, P < 0.01). These results suggest neutrophils are one of the primary effector cells in the early phase of SIV infection in pigs.
- Subjects
GENE expression; SWINE influenza; NEUTROPHILS; SWINE diseases; NUCLEIC acids; IMMUNOHISTOCHEMISTRY; CARDIOPULMONARY system
- Publication
Veterinary Research Communications, 2011, Vol 35, Issue 7, p469
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-011-9488-4