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- Title
Synthesis and biological properties of 5,5-diethyl-2-substituted 4-oxo-3,4,5,6-tetrahydrobenzo[ h]quinazoline derivatives.
- Authors
Markosyan, A. I.; Pogosyan, S. A.; Safaryan, M. S.; Sukasyan, R. S.; Arsenyan, F. G.; Sarkisyan, I. S.; Garibdzhanyan, B. T.
- Abstract
A series of new derivatives of benzo[ h]quinazolines containing diethyl substituents at position 5 were synthesized. The alkylation of some 2-substituted 5,5-diethyl-4-oxo-3,4,5,6-tetrahydrobenzo[ h]quinazolines with methyl iodide led to N-substituted products, while a similar reaction with ethyl iodide led to a mixture of N-substituted and O-substituted products. Some of the synthesized 5,5-diethyl-4-oxo-3,4,5,6-tetrahydrobenzo[ h]quinazolines exhibit pronounced antiaminooxidase and weak antitumor properties.
- Subjects
ALKYLATION; HYDROCARBONS; IODIDES; CHEMICAL reactions; ORGANIC compounds; PHARMACEUTICAL chemistry
- Publication
Pharmaceutical Chemistry Journal, 2007, Vol 41, Issue 4, p193
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-007-0044-z