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- Title
Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease.
- Authors
Kikuta, Hideaki; Taguchi, Yuichi; Tomizawa, Kazuhiro; Kojima, Kimikazu; Kawamura, Nobuaki; Ishizaka, Akihito; Sakiyama, Yukio; Matsumoto, Shuzo; Imai, Shosuke; Kinoshita, Toshifumi; Koizumi, Shigeki; Osato, Toyoro; Kobayashi, Ichiro; Hamada, Isamu; Hirai, Kanji
- Abstract
Epstein-Barr virus (EBV), a ubiquitous human herpesvirus and an aetiological agent of infectious mononucleosis, has a unique trop-ism for B lymphocytes1. Clinical and laboratory features of chronic active EBV infections are chronic or persistent infectious mononu-cleosis-like symptoms and high antibody titre against early anti-gens (EA)2-4 . Kawasaki disease (KD), aetiology unknown, is thought to be self-limited immunologically mediated vasculitis. Clinical features of KD are fever, rash, mucositis, lym-phadenopathy and coronary artery damage5,6. We report here a child with chronic active EBV infection accompanied by dilatation of coronary arteries. All the EBV-determined nuclear antigen (EBNA)-positive lymphocytes had exclusively CD4 antigen, as revealed by dual staining immunofluorescence analysis. Southern blot hybridization showed that the purified CD4+ cells harboured EBV genome.
- Publication
Nature, 1988, Vol 333, Issue 6172, p455
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/333455a0