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- Title
Novel MRI-guided focussed ultrasound stimulated microbubble radiation enhancement treatment for breast cancer.
- Authors
Dasgupta, Archya; Saifuddin, Murtuza; McNabb, Evan; Ho, Ling; Lu, Lin; Vesprini, Danny; Karam, Irene; Soliman, Hany; Chow, Edward; Gandhi, Sonal; Trudeau, Maureen; Tran, William; Curpen, Belinda; Stanisz, Greg; Sahgal, Arjun; Kolios, Michael; Czarnota, Gregory J.
- Abstract
Preclinical studies have demonstrated focused ultrasound (FUS) stimulated microbubble (MB) rupture leads to the activation of acid sphingomyelinase-ceramide pathway in the endothelial cells. When radiotherapy (RT) is delivered concurrently with FUS-MB, apoptotic pathway leads to increased cell death resulting in potent radiosensitization. Here we report the first human trial of using magnetic resonance imaging (MRI) guided FUS-MB treatment in the treatment of breast malignancies. In the phase 1 prospective interventional study, patients with breast cancer were treated with fractionated RT (5 or 10 fractions) to the disease involving breast or chest wall. FUS-MB treatment was delivered before 1st and 5th fractions of RT (within 1 h). Eight patients with 9 tumours were treated. All 7 evaluable patients with at least 3 months follow-up treated for 8 tumours had a complete response in the treated site. The maximum acute toxicity observed was grade 2 dermatitis in 1 site, and grade 1 in 8 treated sites, at one month post RT, which recovered at 3 months. No RT-related late effect or FUS-MB related toxicity was noted. This study demonstrated safety of combined FUS-MB and RT treatment. Promising response rates suggest potential strong radiosensitization effects of the investigational modality. Trial registration: clinicaltrials.gov, identifier NCT04431674.
- Subjects
MICROBUBBLES; BREAST cancer; MAGNETIC resonance imaging; ULTRASONIC imaging; CANCER treatment; CLINICAL trials; RADIOTHERAPY safety
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-40551-5