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- Title
Extracellular concentrations of fosfomycin in lung tissue of septic patients.
- Authors
Matzi, Veronika; Lindenmann, Jörg; Porubsky, Christian; Kugler, Sylvia A.; Maier, Alfred; Dittrich, Peter; Smolle-Jüttner, Freyja M.; Joukhadar, Christian
- Abstract
Objectives: The present investigation explored the ability of fosfomycin to penetrate lung tissue of septic patients by utilizing the microdialysis technique. Methods: After microdialysis probe insertion into healthy and infected lung tissue, a single intravenous dose of 4 g of fosfomycin was administered. Results: The mean Cmax, Tmax, AUC0-4 and AUC0-∞ for healthy lung were 131.6±110.6 mg/L, 1.1±0.4 h, 242.4±101.6 mg.h/L and 367.6±111.9 mg.h/L, respectively. The corresponding values for infected lung were 107.5±60.2 mg/L, 1.4±0.5 h, 203.5±118.4 mg·h/L and 315.1±151.2 mg·h/L. The half-life of fosfomycin ranged from 2.2 to 2.7 h between compartments. The magnitude of lung tissue penetration, as determined by the ratios of the AUC0-∞ for lung to the AUC0-∞ for plasma, was 0.63±0.31 and 0.53±0.31 for healthy and infected lung, respectively. Conclusions: We conclude that fosfomycin achieves antimicrobially effective concentrations in infected lung tissue.
- Subjects
DRUG efficacy; FOSFOMYCIN; SEPSIS; LUNG diseases; CLINICAL drug trials; ANTIBACTERIAL agents; PATIENTS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 5, p995
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkq070