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- Title
Effect of LY333328 against vancomycin-resistant Enterococcus faecium in a rat central venous catheter-associated infection model.
- Authors
Rupp, Mark E.; Fey, Paul D.; Longo, G. Matthew; Rupp, M E; Fey, P D; Longo, G M
- Abstract
A rat central venous catheter (CVC) infection model was used to assess the activity of LY333328 against vancomycin-resistant Enterococcus faecium (VRE). Via the CVC, animals were challenged with 10(6) cfu of Enterococcus faecium with the VanA phenotype. Eight rats received a single dose of LY333328 and eight rats received saline. Seventy-five per cent of control animals had peripheral bacteraemia and 87.5% had VRE recovered from explanted CVCs at the time they were killed, as compared with 0 and 12.5%, respectively, of the LY333328-treated animals (P < 0.01). All animals in the control group had evidence of metastatic disease compared with none of the treated group (P < 0.01). LY333328 was effective against the strain of VRE tested in this model.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2001, Vol 47, Issue 5, p705
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/47.5.705