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- Title
Use of meropenem 3 g once daily for outpatient treatment of infective exacerbations of bronchiectasis.
- Authors
Darley, Elizabeth S. R.; Bowker, Karen E.; Lovering, Andrew M.; Harvey, John E.; Macgowan, Alasdair P.; Darley, E S; Bowker, K E; Lovering, A M; Harvey, J E; Macgowan, A P
- Abstract
Meropenem administered as a single iv 3 g dose once every 24 h was used to treat nine ambulatory patients with infective exacerbations of bronchiectasis. Serum meropenem concentrations were measured before dosing and at 30 min after each 30 min infusion. Mean pre-dose concentrations were <0.1 mg/L and mean post-dose concentrations 93.9 ± 29.5 mg/L (95% confidence interval (CI) 86.2–101.6, n = 59). A pathogen was cultured from sputum in six patients and eradicated (<100 cfu/g sputum) in all but one by day 6 of therapy. Previous work on animals has shown that a bacteriostatic effect is seen with meropenem when t > MIC is greater than 20–30% of the dose interval. In these nine patients, this could be achieved and was associated with successful outcome for pathogens for which MICs are ≤ 0.5 mg/L. Therefore, once-a-day meropenem therapy may be a useful option for outpatient treatment for isolates for which MICs are ≤ 0.5 mg/L.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2000, Vol 45, Issue 2, p247
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/45.2.247