We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Catalase -262C/T Promoter Polymorphism and Aging Phenotypes.
- Authors
Christiansen, Lene; Petersen, Hans Christian; Bathum, Lise; Frederiksen, Henrik; McGue, Matt; Christensen, Kaare
- Abstract
A low level of the central antioxidant enzyme catalase has been suggested to be a risk factor for diseases influenced by oxidative stress. In this study, we investigated the possible association of the catalase -262C/T polymorphism with survival, physical and cognitive functioning, and a number of oxidative stress-mediated disorders. The study population was 2223 Danish individuals, aged 45-93 years, drawn from three population-based surveys. The results suggest that the catalase -262C/T polymorphism is not associated with either survival, or the majority of the age-related phenotypes investigated. However, our data indicate a statistical significant association of TT homozygosity with improved physical functioning as well as a trend of the T allele conferring an improved general cognitive functioning, although these results did not remain significant after correcting for multiple testing. The results raise the hypothesis that the catalase -262T allele serves as protection against neurodegenerative and physical decline, although replication in other studies is warranted for confirmation of these findings.
- Subjects
CATALASE; DISEASE risk factors; ANTIOXIDANTS; OXIDATIVE stress; ENZYMES; PHENOTYPES; NEURODEGENERATION; GENETIC polymorphisms
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2004, Vol 59, Issue 9, p886
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/59.9.B886