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- Title
Swimming Training Prevents Alterations in Acetylcholinesterase and Butyrylcholinesterase Activities in Hypertensive Rats.
- Authors
Cardoso, Andréia Machado; Abdalla, Fátima Husein; Bagatini, Margarete Dulce; Martins, Caroline Curry; da Silva Fiorin, Fernando; Baldissarelli, Jucimara; Costa, Pauline; de Mello, Fábio Fernandes; Fiorenza, Amanda Maino; da Silva Serres, Jonas Daci; Gonçalves, Jamile Fabbrin; Chaves, Heloísa; Royes, Luiz Fernando Freire; Belló-Klein, Adriane; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina
- Abstract
BACKGROUND Cholinergic enzyme activities are altered in hypertension, reflecting a low-grade inflammation. Regular physical exercise exerts anti-inflammatory effects and has been described as a coadjutant in the treatment of hypertension. In this study, we investigated the effect of 6 weeks of swimming training on cholinergic enzyme activities (acetylcholinesterase and butyrylcholinesterase) in Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)–induced hypertensive rats. METHODS The rats were divided into 4 groups: control (n = 10), exercise (n = 10), L-NAME (n = 10), and exercise L-NAME (n = 10). The animals were trained 5 times per week in an adapted swimming system for 60 minutes with a gradual increase of the workload up to 5% of animal’s body weight. Enzyme activities were measured spectrophotometrically in lymphocytes, whole blood, and serum. RESULTS A significant rise in acetylcholinesterase activity was observed in lymphocytes and whole blood as well as in serum butyrylcholinesterase activity in the L-NAME group when compared with the other groups (P < 0.05), and the increase in cholinesterase activities was positively correlated with the rise in blood pressure (r = 0.5721, r = 0.6121, and r = 0.5811, respectively). Swimming training was efficient in preventing these alterations in the exercise L-NAME group, which displayed values similar to those of the control group. Exercise training demonstrated a significant hypotensive effect in hypertensive rats. CONCLUSIONS Exercise training was shown to prevent increased cholinesterase related to inflammatory processes in hypertensive rats, providing a new insight about protective exercise mechanisms to avoid hypertension-related inflammation.
- Subjects
SWIMMING training; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; HYPERTENSION; LABORATORY rats
- Publication
American Journal of Hypertension, 2014, Vol 27, Issue 4, p522
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpt030