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- Title
A Case with Methemoglobinemia due to Use of Dapsone.
- Authors
Aksoy, Emine; Moçin, Özlem Yazıcıoğlu
- Abstract
Methemoglobinemia is a lethal condition that is most commonly seen with use of drugs such as dapsone and Benzocain. Methemoglobinemia associated with dapsone use is a result of decreased oxidation in erythrocytes due to the inhibition of the B5 reductase enzyme. We present here a case who developed methemoglobinemia while taking dapsone 100mg/day for a month due to urticaria. The male patent developed such symptoms as malaise, subfebrile fever, sweating, peri-oral and peripheral cyanosis with exertion, and skin lesions for a week. Oxygen saturation with pulse oxymetry was 88%, and the methemoglobin (MetHb) level in the arterial blood gases (ABG) was 10.7% at time of diagnosis. The patient was monitored, oxygen was initiated and dapsone was discontinued. The patient recovered during follow-up and the MetHb level became normal (2.8%) in ABG on the 7th day, and the cyanosis disappeared. Patients presenting with cyanosis and with no known previous pulmonary or cardiac disease should be evaluated for Methemoglobinemia, and drug history of the patient should also be reviewed.
- Subjects
METHEMOGLOBINEMIA; DAPSONE; OXYGEN saturation; CYANOSIS; BLOOD gases; DRUG utilization
- Publication
Respiratory Case Reports, 2021, Vol 10, Issue 2, p148
- ISSN
2147-2475
- Publication type
Article
- DOI
10.5505/respircase.2021.52385