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- Title
Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002-2011. Part II: concomitant reactions.
- Authors
Geier, Johannes; Lessmann, Holger; Hillen, Uwe; Skudlik, Christoph; Jappe, Uta
- Abstract
Background Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems ( ERSs). Because of chemical similarities, immunological cross-reactivity may occur. Objectives To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs ( FP-0324). Methods A retrospective analysis of data from the Information Network of Departments of Dermatology ( IVDK), 2002-2011, was performed. Results There was close concomitant reactivity to 1,6-hexanediol diglycidyl ether and 1,4-butanediol diglycidyl ether (1,4- BDDGE), and to phenyl glycidyl ether ( PGE) and cresyl glycidyl ether ( CGE), whereas reactions to p-tert-butylphenyl glycidyl ether occurred more independently from those to PGE and CGE. Concomitant reactions to butyl glycidyl ether and 1,4- BDDGE may point to a common allergenic compound derived from the metabolism of 1,4- BDDGE. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross-reactions. Conclusions More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future.
- Subjects
EPOXY resin testing; ALLERGENS; TREATMENT of contact dermatitis; INDUSTRIAL toxicology; SPOT tests (Chemistry)
- Publication
Contact Dermatitis (01051873), 2016, Vol 74, Issue 2, p94
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.12490