We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Usefulness of Imaging and Biological Tools for the Characterization of Portal Vein Thrombosis in Hepatocellular Carcinoma.
- Authors
Burciu, Călin; Șirli, Roxana; Bende, Felix; Fofiu, Renata; Popescu, Alina; Sporea, Ioan; Ghiuchici, Ana-Maria; Miuțescu, Bogdan; Dănilă, Mirela
- Abstract
This study aims to evaluate the performance of contrast-enhanced ultrasound (CEUS) and biological tests to characterize portal vein thrombosis (PVT). We retrospectively analyzed 101 patients with PVT, liver cirrhosis, and hepatocellular carcinoma (HCC). In all patients, demographic, biologic, imaging, and endoscopic data were collected. All patients underwent CEUS and a second line imaging technique (CE-CT/MRI) to characterize PVT. Of the 101 cirrhotic subjects, 77 (76.2%) had HCC. CEUS had 98.6% sensitivity (Se) and 89.3% specificity (Sp) for the characterization of PVT type. A significant correlation was found between alpha-fetoprotein (AFP) levels and the PVT characterization at CEUS (r = 0.28, p = 0.0098) and CT/MRI (r = 0.3, p = 0.0057). Using the AFP rule-out cutoff values for HCC (AFP < 20 ng/dL), 78% of the subjects were correctly classified as having benign PVT, while 100% of the subjects were correctly classified as tumor-in-vein (TIV) when the rule-in cutoff value was used (AFP ≥ 200 ng/dL). Using multiple regression analysis, we obtained a score for classifying PVT. The PVT score performed better than CEUS (AUC—0.99 vs. AUC—0.93, p = 0.025) or AFP serum levels (AUC—0.99 vs. AUC—0.96, p = 0.047) for characterizing PVT. In conclusion, CEUS is a sensitive method for the characterization of PVT. The PVT score had the highest performance for PVT characterization.
- Subjects
PORTAL vein; HEPATOCELLULAR carcinoma; CONTRAST-enhanced ultrasound; THROMBOSIS; MULTIPLE regression analysis
- Publication
Diagnostics (2075-4418), 2022, Vol 12, Issue 5, pN.PAG
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics12051145