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- Title
BJORNTORP FELLOWSHIP AW0006 The involvement of galanin-like peptide in energy balance: a role for inflammation?
- Authors
Lawrence, C. B.; Allan, S. M.; Rothwell, N. J.; Luckman, S. M.
- Abstract
Galanin-like peptide (GALP) is thought to play a role in energy balance within the central nervous system. Experimental evidence shows that GALP has dichotomous actions on energy homeostasis; producing orexigenic effects in the short-term, but anorexigenic effects over the longer-term. These anorexic actions of GALP are very similar to that seen after peripheral or central injection of the cytokine interleukin-1 (IL-1). Thus the aim of this study was to test the hypothesis that IL-1 mediates the effects of GALP on energy balance. Intracerebroventricular (icv) injection of GALP (1.6 nmol) in male Sprague-Dawley rats stimulated food intake over 1 h, but decreased feeding, body weight at 24 h and cause a rise in core body temperature over 8 h (indirect evidence of an increase in energy expenditure). These longer-term actions were inhibited by co-infusion of the IL-1 receptor antagonist, IL-1ra. However, IL-1ra had no effect on GALP-induced acute stimulation of feeding. GALP injection (icv) also stimulated production of IL-1 protein in selected brain areas, such as the periventricular brain region and these IL-1 expressing cells were microglia. These data suggest GALP induces expression of IL-1 in the brain and the anorexic and febrile actions of GALP are mediated by this cytokine.
- Subjects
NEUROPEPTIDES; CENTRAL nervous system; HOMEOSTASIS; APPETITE stimulants; CYTOKINES; MICROGLIA; INTERLEUKIN-1
- Publication
Obesity Reviews, 2006, Vol 7, p36
- ISSN
1467-7881
- Publication type
Article
- DOI
10.1111/j.1467-7881.2006.00280_5.x