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- Title
Nephro-urological complications of epidermolysis bullosa in paediatric patients.
- Authors
Chan, S. M. H.; Dillon, M. J.; Duffy, P. G.; Atherton, D. J.
- Abstract
A small but important proportion of patients with epidermolysis bullosa (EB) may develop significant renal and urological complications which can have a major impact on their morbidity and mortality. During the last 10 years, five of a large group of children with EB under our care, with either dystrophic or junctional types of disease, experienced major nephro-urological complications. Two patients with recessive dystrophic EB (REDB) developed macroscopic haematuria - one had renal failure and underwent a renal biopsy showing IgA nephropathy. A third patient with RDEB also developed renal failure and his biopsy demonstrated postinfectious glomerulonephritis/type III membranoproliferative (mesangiocapillary) glomerulonephritis. Both patients with renal failure underwent peritoneal dialysis. Two patients with junctional EB developed obstructive uropathies, which required bladder reconstruction and the fashioning of a Mitrofanoff channel in one.
- Subjects
EPIDERMOLYSIS bullosa; DISEASE complications; MORTALITY; HEMATURIA; KIDNEY diseases; GLOMERULONEPHRITIS
- Publication
British Journal of Dermatology, 2007, Vol 156, Issue 1, p143
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.2006.07516.x