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- Title
Risk factors associated with late cytomegalovirus reactivation after allogeneic stem cell transplantation for hematological malignancies.
- Authors
Özdemir, E.; Saliba, R. M.; Champlin, R. E.; Couriel, D. R.; Giralt, S. A.; de Lima, M.; Khouri, I. F.; Hosing, C.; Kornblau, S. M.; Anderlini, P.; Shpall, E. J.; Qazilbash, M. H.; Molldrem, J. J.; Chemaly, R. F.; Komanduri, K. V.
- Abstract
We analyzed the clinical factors associated with late cytomegalovirus (CMV) reactivation in a group of 269 consecutive recipients of allogeneic stem cell transplant (SCT) for hematological malignancies. Eighty-four subjects (31%) experienced late CMV reactivation, including 64 with prior early reactivation and 20 with isolated late reactivation. Multivariate analyses were conducted in patients with early CMV reactivation to identify factors associated with late recurrence. Important risk factors included lymphoid diagnosis, occurrence of graft-versus-host disease (GVHD), greater number of episodes of early reactivation, persistent day 100 lymphopenia and the use of a CMV-seronegative donor graft. We combined these risk factors in a predictive model to identify those at relatively low, intermediate and high risk. The low-risk group (15% cumulative incidence, CI) encompassed patients without early CMV reactivation, and subjects transplanted for a myeloid malignancy from a matched-related (MR) donor without subsequent acute GVHD. The high-risk patients (73% CI) met all of the following criteria: (1) received an MR graft but developed GVHD, or received a non-MR graft irrespective of GVHD; (2) had more than two episodes of early reactivation; and (3) received a CMV-seronegative graft and/or remained persistently lymphopenic at day 100 after SCT. The remaining patients had an intermediate incidence of 32%.Bone Marrow Transplantation (2007) 40, 125–136; doi:10.1038/sj.bmt.1705699; published online 28 May 2007
- Subjects
CYTOMEGALOVIRUS diseases; HERPESVIRUS diseases; CYTOMEGALIC inclusion disease; STEM cell transplantation; GRAFT versus host disease; HOMOGRAFTS; BONE marrow transplant complications
- Publication
Bone Marrow Transplantation, 2007, Vol 40, Issue 2, p125
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705699