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- Title
Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis.
- Authors
Lushan Peng; Dan Wang; Yingying Han; Tao Huang; Xiaoyun He; Junpu Wang; Chunlin Ou
- Abstract
Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell population in the tumor microenvironment and play an irreplaceable role in oncogenesis and cancer progression. Exosomes, a class of small extracellular vesicles, can transfer biological information (e.g., proteins, nucleic acids, and metabolites as messengers) from secreting cells to target recipient cells, thereby affecting the progression of human diseases, including cancers. Recent studies revealed that CAF-derived exosomes play a crucial part in tumorigenesis, tumor cell proliferation, metastasis, drug resistance, and the immune response. Moreover, aberrant expression of CAF-derived exosomal noncoding RNAs and proteins strongly correlates with clinical pathological characterizations of cancer patients. Gaining deeper insight into the participation of CAF-derived exosomes in tumorigenesis may lead to novel diagnostic biomarkers and therapeutic targets in human cancers.
- Subjects
EXOSOMES; EXTRACELLULAR vesicles; CELL populations; CELL anatomy; NEOPLASTIC cell transformation
- Publication
Frontiers in Immunology, 2022, Vol 12, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2021.795372