We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
- Authors
Kobayashi, Azusa; Ito, Ayaka; Shirakawa, Ibuki; Tamura, Atsushi; Tomono, Susumu; Shindou, Hideo; Hedde, Per Niklas; Tanaka, Miyako; Tsuboi, Naotake; Ishimoto, Takuji; Akashi-Takamura, Sachiko; Maruyama, Shoichi; Suganami, Takayoshi
- Abstract
Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To determine whether the fatty acid composition of diet modulates leukocyte function and the development of systemic lupus erythematosus, we examined the effect of eicosapentaenoic acid (EPA) on the pathology of lupus in drug-induced and spontaneous mouse models. We found that dietary EPA supplementation ameliorated representative lupus manifestations, including autoantibody production and immunocomplex deposition in the kidneys. A combination of lipidomic and membrane dynamics analyses revealed that EPA remodels the lipid composition and fluidity of B cell membranes, thereby preventing B cell differentiation into autoantibody-producing plasma cells. These results highlight a previously unrecognized mechanism by which fatty acid composition affects B cell differentiation into autoantibody-producing plasma cells during autoimmunity, and imply that EPA supplementation may be beneficial for therapy of lupus.
- Subjects
UNITED States. Environmental Protection Agency; PLASMA cells; EICOSAPENTAENOIC acid; B cell differentiation; DIETARY supplements; CELL differentiation; ARACHIDONIC acid; ALPHA-linolenic acid
- Publication
Frontiers in Immunology, 2021, Vol 12, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2021.650856