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- Title
Cover Picture: Eur. J. Immunol. 4'17.
- Abstract
Our front cover features a digital reconstruction of chemotactic receptor CXCR2 bound to CXCL8 (IL‐8) or GRPR antagonist on the cell membrane. CXCR2 (yellow) is crucial for neutrophil recruitment by CXCL8 (blue) upon binding the receptor's extracellular domains on the cell membrane (green). The image is taken from Czepielewski and Jaeger et al. (pp. 646–657), where the authors predict that a GRPR antagonist (red) binds the same pocket in CXCR2, preventing CXCL8‐ (in human) or CXCL2 (in mouse)‐induced neutrophil activation and recruitment in a model of drug‐induced liver injury, through the impairment of neutrophil migration. Authors demonstrate this antagonist protects mice from acute liver injury after acetaminophen overdose and propose it as a novel anti‐inflammatory molecule for neutrophil‐associated pathologies.
- Publication
European Journal of Immunology, 2017, Vol 47, Issue 4, pNA
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201770040