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- Title
Hypoxia controls CD4.
- Authors
Ben-Shoshan, Jeremy; Maysel-Auslender, Sophia; Mor, Adi; Keren, Gad; George, Jacob
- Abstract
Recent data suggest that hypoxia and its principal molecular signature HIF-1 (hypoxia-inducing factor-1) may tune down inflammation by dictating anti-inflammatory programs. We tested the effects of hypoxia and HIF-1α on the homeostasis of naturally occurring regulatory T cells (Treg) and their transcriptional activator Foxp3. Hypoxia induced a time-dependent increase in HIF-1α in mouse and human T cells. Hypoxia upregulated the expression of Foxp3 in Jurkat T cells, human and murine mononuclear cells. The effects of hypoxia on Foxp3 expression were HIF-1α-dependent as they were abolished upon transfection with short-interfering RNAs for HIF-1α and promoted by HIF-1α overexpression. Hypoxia increased the potency of Treg, as hypoxic CD4
- Publication
European Journal of Immunology, 2008, Vol 38, Issue 9, p2412
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200838318