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- Title
Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort.
- Authors
Wirfält, E.; Paulsson, B.; Törnqvist, M.; Axmon, A.; Hagmar, L.
- Abstract
Objective:To examine the coherence of estimated intakes of acrylamide (AA) from foods, with hemoglobin (Hb) AA adduct levels, an objective marker of environmental AA exposure.Design:A cross-sectional study.Setting:The Malmö Diet and Cancer study, a large population-based prospective cohort (n=28 098) in the south of Sweden.Subjects:A sample of non-smoking (n=70) and smoking (n=72) women and men selected to obtain large variation in Hb AA adducts.Methods:Self-reported data on the usual consumption of foods were combined with published data on the AA content in Swedish foods. The Hb AA adduct levels were determined by a modified Edman degradation method. Linear regression and correlation analysis examined associations between estimated AA intakes, and Hb AA adducts.Results:In randomly selected individuals (n=40), the estimated median AA intake was 28 μg per day. In linear regression models, adjusting for sex, significant associations were seen in non-smokers between Hb AA adducts and estimated AA from foods (P=0.006). In smokers both AA from foods (P=0.006) and the calculated amount of tobacco consumed (P=0.003) were significantly associated with Hb AA adducts. Positive partial correlations between dietary AA estimates and Hb AA adducts were seen in smoking men (r=0.37) and women (r=0.59), and in non-smoking men (r=0.60), but not in non-smoking women.Conclusions:This study suggests that both diet and tobacco are important sources of the environmental AA exposure, although the lack of correlations in non-smoking women cast doubt on the validity of dietary AA intake estimates used in cancer epidemiology, or suggest that unrecognized factors may influence the internal dose measure of AA exposure.Sponsorship:Funded by the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS); the European Commission (Contract no FOOD-CT-2003–506820, HEATOX); The Swedish Cancer Society; The Swedish Research Council; and The City of Malmö.European Journal of Clinical Nutrition (2008) 62, 314–323; doi:10.1038/sj.ejcn.1602704; published online 14 March 2007
- Subjects
SWEDEN; ACRYLAMIDE; NUTRITION; HEMOGLOBINS; TOBACCO use; CANCER in women
- Publication
European Journal of Clinical Nutrition, 2008, Vol 62, Issue 3, p314
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/sj.ejcn.1602704