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- Title
Berberine: A novel therapeutic strategy for cancer.
- Authors
Samadi, Parisa; Sarvarian, Parisa; Gholipour, Elham; Asenjan, Karim Shams; Aghebati‐Maleki, Leili; Motavalli, Roza; Hojjat‐Farsangi, Mohammad; Yousefi, Mehdi
- Abstract
Cancer, even currently, is one of the main reasons for mortality and morbidity, worldwide. In recent years, a great deal of effort has been made to find efficient therapeutic strategies for cancer, however, particularly with regards to side effects and the possibility of complete remission. Berberine (BBR) is a nature‐driven phytochemical component originated from different plant groups such as Berberis vulgaris, Berberis aquifolium, and Berberis aristata. BBR is a well‐known nutraceutical because of its wide range of pharmacological activities including anti‐inflammatory, antidiabetic, antibacterial, antiparasitic, antidiarrheal, antihypertensive, hypolipidemic, and fungicide. In addition, it exhibits inhibitory effects on multiple types of cancers. In this review, we have elaborated on the anticancer effects of BBR through the regulation of different molecular pathways such as: inducing apoptosis, autophagy, arresting cell cycle, and inhibiting metastasis and invasion.
- Subjects
BERBERINE; BARBERRIES; APOPTOSIS; CANCER; CELL cycle; DRUG side effects
- Publication
IUBMB Life, 2020, Vol 72, Issue 10, p2065
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.2350