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- Title
Improvement effect of evodiae fructus water extract against DSS-induced ulcerative colitis.
- Authors
Kim, Min; Lee, Jin; Shin, Mi-Rae; Lee, Ji; Park, Hae-Jin; Lee, Sanghyun; Roh, Seong-Soo
- Abstract
Background: Evodiae fructus is a natural plant that is used as a medicinal material in many Asian countries such as Korea and China. However, little is known about its effect on ulcerative colitis. Objectives: Thus, the purpose of this study was to find the improvement effect of Evodiae fructus in mice model with dextran sulfate sodium (DSS)-induced colitis. Materials and Methods: The animal experiments were conducted using ulcerative colitis animals induced by DSS. To induce ulcerative colitis in BALB/c mice used in the experiment, 5% DSS was supplied as drinking water for 7 days. BALB/c mice were divided into five groups (n = 8): Group 1 (normal group), Group 2 (5% DSS control group), Group 3 (5% DSS + sulfasalazine 60 mg/kg treated), Group 4 (5% DSS + Evodiae fructus water extract 50 mg/kg treated), Group 5 (5% DSS + Evodiae fructus water extract 100 mg/kg treated). After the animal experiment, the expression of antioxidant, oxidative stress, inflammatory, and necrosis-related factors in colonic tissues was analyzed by western blotting. Results: As a result, the Evodiae fructus treatment group reduced oxidative stress by increasing the expression of Nrf2, an antioxidant-related transcription factor. Also, the expression of NF-κB, an inflammatory transcription factor, was reduced, thereby reducing the expression of pro-inflammatory proteins and inflammatory cytokines. Conclusion: These results suggest that Evodiae fructus treatment has an inhibitory effect on inflammation against DSS-induced colitis. Therefore, Evodiae fructus has the potential to be used as a natural medicine for ulcerative colitis.
- Subjects
SOUTH Korea; CHINA; ULCERATIVE colitis; DEXTRAN sulfate; SODIUM sulfate; TRANSCRIPTION factors; WESTERN immunoblotting; INFLAMMATORY bowel diseases
- Publication
Pharmacognosy Magazine, 2022, Vol 18, Issue 78, p450
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/pm.pm_465_21