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- Title
Galectin-3 Reflects Left Atrial Function being Assessed by Cardiac Magnetic Resonance Imaging.
- Authors
Seung-Hyun Kim; Behnes, Michael; Natale, Michèle; Hamed, Sonja; Hoffmann, Julia; Hoffmann, Ursula; Budjan, Johannes; Lang, Siegfried; Borggrefe, Martin; Papavassiliu, Theano; Bertsch, Thomas; Akin, Ibrahim
- Abstract
Background: This study aims to evaluate the association between galectin-3 and left atrial function (LAF) in patients undergoing cMRI. Methods: Patients undergoing cMRI were prospectively enrolled. Right ventricular dysfunction (< 50%) was excluded. Blood samples for biomarker measurements of galectin-3 and NT-proBNP were collected at the time of cMRI examination. Results: A total of 84 patients were included. Median LVEF was 59% (IQR 51 - 64%). Galectin-3 was inversely correlated with overall LAF within a multivariable linear regression model (Beta -0.27; T -2.54; p = 0.01). Galectin-3 increased significantly according to the different stages of impaired LAF (p = 0.003) and was able to discriminate both patients with impaired LAF < 55% (AUC = 0.70, p = 0.002) and LAF < 45% (AUC = 0.69, p = 0.004). In multivariable logistic regression models, galectin-3 was still associated with impaired LAF (LAF < 55%: OR = 2.64, p = 0.07; LAF < 45%: OR = 6.65, p = 0.007). Conclusions: This study demonstrates that galectin-3 is able to reflect LAF being assessed by cMRI.
- Subjects
GALECTINS; MAGNETIC resonance imaging; CARDIAC imaging; HEART ventricle diseases; HEART ventricle abnormalities
- Publication
Clinical Laboratory, 2017, Issue 10, p1701
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2017.170507