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- Title
Maternal Viral Genotypic Zidovudine Resistance and Infrequent Failure of Zidovudine Therapy to Prevent Perinatal Transmission of Human Immunodeficiency Virus Type 1 in Pediatric AIDS Clinical Trials Group Protocol 076.
- Authors
Eastman, P. Scott; Shapiro, David E.; Coombs, Robert W.; Frenkel, Lisa M.; McSherry, George D.; Britto, Paula; Herman, Steven A.; Sperling, Rhoda S.
- Abstract
Maternal samples were assessed from 96 women enrolled in Pediatric AIDS Clinical Trials Group protocol 076 to determine the prevalence of human immunodeficiency virus type 1 (HIV-1) genotypic zidovudine resistance at entry, if zidovudine resistance developed on study, and the role of zidovudine resistance in vertical transmission of HIV-1 despite zidovudine therapy. Low and high levels of genotypic resistance were assessed by differential hybridization, oligoligation, or direct sequencing of plasma HIV-1 RNA for codons K70R and T215Y/F. None of the women had high-level genotypic resistance to zidovudine at study entry or delivery. For low-level zidovudine resistance, the 95% confidence intervals were 0.3%–6.8% for baseline prevalence and 0.3%–14% for delivery incidence. Low-level zidovudine resistance, adjusted for plasma viral RNA level at delivery, was not strongly associated with an increase in vertical transmission risk (odds ratio, 4.8; 95% confidence interval, 0.2–131; P = .35).
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 3, p557
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/514228