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- Title
Neuropathogenesis Induced by Rhesus Cytomegalovirus in Fetal Rhesus Monkeys (Macaca mulatta).
- Authors
Tarantal, Alice F.; Salamat, M. Shahriar; Britt, William J.; Luciw, Paul A.; Hendrickx, Andrew G.; Barry, Peter A.
- Abstract
Rhesus cytomegalovirus (RhCMV) infection of rhesus macaques offers opportunities to analyze mechanisms of CMV pathogenesis in a primate species. Four fetal rhesus monkeys were inoculated intraperitoneally with RhCMV early in the second trimester, and pregnancies were terminated by hysterotomy during the third trimester. Three fetuses had evidence of severe CMV disease, including intrauterine growth restriction, ventriculomegaly, microcephaly, lissencephaly, and extensive degenerative changes of the cerebral parenchyma. Histopathologic examination revealed polymicrogyria, gliosis, leptomeningitis, periventricular calcifications, and inclusion-bearing cells. These results demonstrate that the developing macaque brain is susceptible to infection with RhCMV early in the second trimester and that intrauterine infection results in neuropathologic outcomes similar to those observed in humans congenitally infected with CMV.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 2, p446
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/514206