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- Title
Influenza A Virus-Induced Acute Otitis Media.
- Authors
Buchman, Craig A.; Doyle, William J.; Skoner, David P.; Post, J. Christopher; Alper, Cuneyt M.; Seroky, James T.; Anderson, Kenneth; Preston, Robert A.; Hayden, Frederick G.; Fireman, Philip; Ehrlich, Garth D.
- Abstract
To better understand the significanceof viral upper respiratory tract infections in the pathogenesis of acute otitis media (OM), 27 adults underwent intranasal inoculation with influenza A virus. Monitoring consisted of antibody titer determination, tympanometry, and otoscopy. Microbiologic analysis consisted of cultures and polymerase chain reaction (PCR)-based detection for influenza A virus, Streptococcus pneumoniae, Haemophilus infiuenzae, and Moraxella catarrhalis. All subjects became infected with the challenge virus. By day 4, 16 (59%) developed middle ear pressures of −100 mm H2O or below and 4 (25%) of them developed OM. One subject (4%) developed purulent OM requiring myringotomy for pain relief. Middle ear effusion cultures were negative. PCR analysis of that subject's middle ear effusion and nasal washes were positive for influenza A virus and S. pneumoniae. These findings support a causal role for viral upper respiratory tract infections in the pathogenesis of OM, possibly mediated by middle ear underpressures and viral and bacterial middle ear infection.
- Publication
Journal of Infectious Diseases, 1995, Vol 172, Issue 5, p1348
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/172.5.1348