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- Title
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response.
- Authors
Mendoza, Ana; Álvarez‐Román, María Teresa; Monzón‐Manzano, Elena; Acuña, Paula; Arias‐Salgado, Elena G.; Rivas‐Pollmar, Isabel; Martín‐Salces, Mónica; Martínez de Miguel, Bárbara; Martínez Montalbán, Elena; Jiménez‐Yuste, Víctor; Butta, Nora
- Abstract
Summary: Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and its possible related complications prove the need for further research into potential predictors of response. The platelet sequestration site determined by 111In‐labelled autologous platelet scintigraphy has been proposed to predict splenectomy outcome, but without standardisation in clinical practice. Here, we conducted a single‐centre study by analysing a cohort of splenectomised patients with ITP in whom 111In‐scintigraphy was performed at La Paz University Hospital in Madrid to evaluate the predictive value of the platelet kinetic studies. We also studied other factors that could impact the splenectomy outcome, such as patient and platelet characteristics. A total of 51 patients were splenectomised, and 82.3% responded. The splenic sequestration pattern predicted a higher rate of complete response up to 12 months after splenectomy (p = 0.005), with 90% sensitivity and 77% specificity. Neither age, comorbidities, therapy lines nor previous response to them showed any association with response. Results from the platelet characteristics analysis revealed a significant loss of sialic acid in platelets from the non‐responding patients compared with those who maintained a response (p = 0.0017). Our findings highlight the value of splenic sequestration as an independent predictor of splenectomy response.
- Subjects
MADRID (Spain); IDIOPATHIC thrombocytopenic purpura; SPLENECTOMY; BLOOD platelets; SIALIC acids; UNIVERSITY hospitals
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 1, p315
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19145