We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.
- Authors
Young, Lorraine E.; Fernandes, Kenneth; McEvoy, Tom G.; Butterwith, Simon C.; Gutierrez, Carlos G.; Carolan, Catherine; Broadbent, Peter J.; Robinson, John J.; Wilmut, Ian; Sinclair, Kevin D.
- Abstract
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.
- Subjects
LIVESTOCK; GENETIC disorders; EPIGENESIS
- Publication
Nature Genetics, 2001, Vol 27, Issue 2, p153
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/84769