We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Comparison of the effect of plasma glucose concentrations on microvascular disease between Pima Indian youths and adults.
- Authors
Krakoff, Jonathan; Hanson, Robert L.; Kobes, Sayuko; Knowler, William C.; Krakoff, J; Hanson, R L; Kobes, S; Knowler, W C
- Abstract
<bold>Objective: </bold>To examine whether the current adult guidelines for diagnosis of diabetes are applicable to youth (age <20 years).<bold>Research Design and Methods: </bold>We analyzed fasting plasma glucose (FPG) and 2-h plasma glucose (PG) in two groups of Pima Indians, youths aged 5-19 years and adults aged 20-34 years, in relation to the incidence of microvascular disease when subjects were reexamined at ages 25-39 (youths) and 40-54 (adults). Microvascular disease was defined as retinopathy or a urine protein-to-creatinine ratio > or =0.5 g.<bold>Results: </bold>An increase in the incidence of microvascular disease occurred at nearly the same level of glycemia in both groups. For youths, this increase occurred at FPG approximately 7.3 mmol/l and 2-h PG approximately 10.0 mmol/l; for adults, this increase occurred at FPG approximately 7.5 mmol/l and 2-h PG approximately 10.3 mmol/l. Sensitivity of the adult diagnostic guidelines of FPG > or =7.0 mmol/l and 2-h PG > or =11.1 mmol/l for the detection of microvascular disease was much lower (with higher specificity) in youths than in adults. Receiver operating characteristics (ROC) curve areas were lower for FPG and 2-h PG for youths, suggesting that microvascular disease was less strongly predicted by baseline glucose.<bold>Conclusion: </bold>The current adult guidelines for diagnosis of diabetes are applicable to youth, as they identify a population at high risk of microvascular complications.
- Subjects
DIAGNOSIS of diabetes; MICROCIRCULATION disorders; PIMA (North American people); HEALTH
- Publication
Diabetes Care, 2001, Vol 24, Issue 6, p1023
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.24.6.1023