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- Title
Kinetically and thermodynamically controlled one-pot growth of gold nanoshells with NIR-II absorption for multimodal imaging-guided photothermal therapy.
- Authors
Chen, Ming; Chen, Xiao-Tong; Zhang, Lian-Ying; Meng, Wei; Chen, Yong-Jian; Zhang, Ying-Shan; Chen, Zhi-Cong; Wang, Hui-Min; Luo, Chun-Mei; Shi, Xiu-Dong; Zhang, Wen-Hua; Wang, Mao-Sheng; Chen, Jin-Xiang
- Abstract
Since the successful clinical trial of AuroShell for photothermal therapy, there is currently intense interest in developing gold-based core-shell structures with near-infrared (NIR) absorption ranging from NIR-I (650–900 nm) to NIR-II (900–1700 nm). Here, we propose a seed-mediated successive growth approach to produce gold nanoshells on the surface of the nanoscale metal–organic framework (NMOF) of UiO-66-NH2 (UiO = the University of Oslo) in one pot. The key to this strategy is to modulate the proportion of the formaldehyde (reductant) and its regulator / oxidative product of formic acid to harness the particle nucleation and growth rate within the same system. The gold nanoshells propagate through a well-oriented and controllable diffusion growth pattern (points → facets → octahedron), which has not been identified. Most strikingly, the gold nanoshells prepared hereby exhibit an exceedingly broad and strong absorption in NIR-II with a peak beyond 1300 nm and outstanding photothermal conversion efficiency of 74.0%. Owing to such superior performance, these gold nanoshells show promising outcomes in photoacoustic (PA), computed tomography (CT), and photothermal imaging-guided photothermal therapy (PTT) for breast cancer, as demonstrated both in vitro and in vivo.
- Subjects
UNIVERSITETET i Oslo; GOLD; PHOTOTHERMAL conversion; DISCONTINUOUS precipitation; RATE of nucleation; METAL-organic frameworks; INFRARED radiometry; INFRARED absorption
- Publication
Journal of Nanobiotechnology, 2023, Vol 21, Issue 1, p1
- ISSN
1477-3155
- Publication type
Article
- DOI
10.1186/s12951-023-01907-1