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- Title
Comparing Low Volume Versus Conventional Volume of Polyethylene Glycol for Bowel Preparation during Colonoscopy: A Randomised Controlled Trial.
- Authors
Muhammad Faeid OTHMAN; Andee Dzulkarnaen ZAKARIA; Maya Mazuwin YAHYA; Mohd Nizam MD HASHIM; Wan Mokhzani WAN MOKHTER; Wan Zainira WAN ZAIN; Ikhwan Sani MOHAMAD; Mohd Shahrulsalam MOHD SHAH; Syed Hassan SYED ABD AZIZ; Mohd Nasrullah NIK AB KADIR; Zaidi ZAKARIA; Pak-Kai WONG, Michael
- Abstract
Background: Polyethylene glycol (PEG) solution is widely used as a colonoscopic bowel cleaning agent, although some patients are intolerant due to the need for ingesting large solution volumes and unpleasant taste. A low-volume solution may enhance patient tolerability and compliance in bowel preparation. Accordingly, this study compared the effectiveness of two difference PEG volumes for bowel preparation before colonoscopy in terms of bowel cleanliness, completeness of colonoscopy, patient tolerability and colonoscopy duration. Methods: Using a prospective randomised controlled single-blinded study design, 164 patients scheduled for colonoscopy were allocated to two groups (n = 82 patients in each) to receive either the conventional PEG volume (3 L, control group) or the low volume (2 L, intervention group). The Boston Bowel Preparation Scale (BBPS), a validated scale for assessing bowel cleanliness during colonoscopy, was used to score bowel cleanliness in three colon segments. Secondarily, colonoscopy completeness, tolerability to drinking PEG and the duration of colonoscopy were compared between the groups. Results: There were no statistically significant differences between the two intervention groups in terms of bowel cleanliness (P = 0.119), colonoscopy completion (P = 0.535), tolerability (P = 0.190) or the amount of sedation/analgesia required (midazolam, P = 0.162; pethidine, P = 0.708). Only the duration of colonoscopy differed between the two groups (longer duration in the control group, P = 0.039). Conclusion: Low-volume (2 L) PEG is as effective as the standard 3 L solution in bowel cleaning before colonoscopy; however, the superiority of either solution could not be established.
- Subjects
COLONOSCOPY; DRUG tolerance; BOWEL preparation (Procedure); TIME; PATIENT satisfaction; TREATMENT effectiveness; RANDOMIZED controlled trials; POLYETHYLENE glycol; RESEARCH funding; DESCRIPTIVE statistics; CHI-squared test; DATA analysis software; LONGITUDINAL method
- Publication
Malaysian Journal of Medical Sciences, 2023, Vol 30, Issue 5, p106
- ISSN
1394-195X
- Publication type
Article
- DOI
10.21315/mjms2023.30.5.9