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- Title
Arginine prevents renal tubulointerstitium from fibrosis after massive small bowel resection.
- Authors
Hebiguehi, Tatsuzo; Kato, Tetsuo; Yoshino, Hiroaki; Yamada, Mamiko; Wakui, Hideki; Komatsuda, Atsushi; Imai, Hirokazu
- Abstract
Aim : Our experiment was designed to clarify whether massive small bowel resection induces tubulointerstitial fibrosis (TIF) in the kidney and arginine (Arg) administration can prevent tubulointerstitium from it after massive small bowel resection. Methods: Four-week-old male SD rats underwent 90% proximal small bowel resection (90% SBR). Thereafter, they were divided into 3 groups such as G-1,G-2 and G-3. They were kept by elemental diet (Elental-P, ED-P) with or without Art supplementation in G-1 and G-2 for 6 weeks after surgery, respectively. In G-3, ED-P without Arg supplementation was given for 3 weeks. Thereafter, their food was changed to ED-P with Arg supplementation for 3 weeks. Pair-fed control rats underwent simple anastomosis, and ED -P with or without Arg supplementation was given for 6weeks, respectively. They were sacrificed 6 weeks after surgery. Results : In G-2, low plasma levels of Cit and Arg, increased urinary excretion of orotate, and TIF were observed 6 weeks after surgery. In G-1 and pair-fed control groups, renal histology showed normal glomeruli and tubulointerstitium However, TIF was still observed in G-3. Conclusion : Arg deficiency causes TIF in the kidney following massive small bowel resection.
- Subjects
ARGININE; FIBROSIS; GASTRECTOMY; KIDNEY diseases; LABORATORY rats
- Publication
Asia Pacific Journal of Clinical Nutrition, 2002, Vol 11, pS50
- ISSN
0964-7058
- Publication type
Article