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- Title
Randomized prospective trial of the severity of irritative symptoms after HoLEP vs ThuFLEP.
- Authors
Enikeev, Dmitry; Taratkin, Mark; Babaevskaya, Diana; Morozov, Andrey; Petov, Vladislav; Sukhanov, Roman; Shpot, Evgeny; Misrai, Vincent; Chinenov, Denis; Enikeev, Mikhail; Herrmann, Thomas
- Abstract
Purpose: To compare the short-term postoperative functional outcomes and severity of irritative symptoms following holmium and thulium fiber laser enucleation (HoLEP and ThuFLEP). Methods: This prospective randomized single-blinded study was performed in accordance with CONSORT. The inclusion criteria were IPSS > 20 or Qmax < 10 ml/s. Patients were randomized between HoLEP and ThuFLEP. Demographics, objective data (PSA, prostate volume, etc.), data on urinary and sexual function (IPSS, IIEF, QoL, QUID, Qmax, ICIQ-MLUTS) were collected. Detailed perioperative information and postoperative data on functional outcomes at 1, 2, 3, 4, 6, 8, 10, 12 weeks and 6 months were collected. Results: Data on 163 participants were included (77—HoLEP, 86—ThuFLEP). No differences were found in surgery duration; number of postoperative complications (Clavien–Dindo I-III), catheterization time and hospital stay. Functional outcomes up to 6 months didn't differ between the groups (IPPS, IIEF, QoL, QUID, ICIQ-MLUTS, Qmax, p > 0.05). Total ICIQ‐MLUTS, bother and voiding scores at 1 and 3 months significantly increased compared with the baseline in both groups (p < 0.05). No difference between the groups were observed. In HoLEP the SUI series rate was 1.3% and 1.3% after 3 and 6 months following the procedure; in ThuFLEP: it was 3.5% and 2.3% respectively (p = 0.35 and p = 0.54). Conclusion: The preliminary results of the study showed no apparent differences in functional outcomes (IPSS, Qmax), rate of SUI or irritative symptoms. Both ThuFLEP and HoLEP are efficient ways of treating benign prostatic obstruction. Both surgeries are comparable in terms of duration and postoperative complication rates.
- Subjects
SURGICAL enucleation; FIBER lasers; SURGICAL complications; LASER lithotripsy; SYMPTOMS; ENUCLEATION of the eye; FUNCTIONAL status
- Publication
World Journal of Urology, 2022, Vol 40, Issue 8, p2047
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-022-04046-8