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- Title
Structural remodelling of lungs in chronic heart failure.
- Authors
Kingsbury, Martyn P.; Wenxin Huang; Donnelly, J. Leo; Jackson, Emma; Needham, Emma; Turner, Mark A.; Sheridan, Desmond J.
- Abstract
In order to determine whether morphological changes could account for a previously reported reduction in pulmonary capillary filtration in heart failure, we studied pulmonary morphology in lungs from a guineapig chronic heart failure model. Heart failure was induced by banding the ascending aorta with sham operated animals serving as controls; all animals were studied at 158 ± 6 days post-operation. Following banding, a reduction in aortic flow, increased peripheral vascular resistance and raised left ventricular end diastolic, left atrial and right ventricular pressures together with increased right ventricle to body weight ratio (all p < 0.05) are indicative of established pulmonary hypertension and heart failure. This was associated with an increase in pulmonary septal volume fraction (38.1 ± 3.1% vs 24.6 ± 2.3 %, p < 0.01) and reticulin fibre density. There was also evidence of siderophage infiltration and examination of pulmonary ultra structure revealed a significantly thicker alveolar-capillary barrier in heart failure (1278 ±76 vs 638 ± 32 nm, p < 0.001), thickening of both the alveolar (89%, p < 0.01) and capillary (69%, p < 0.05) basal laminae with pericyte and collagen infiltration of the alveolar-capillary barrier. We hypothesise that these pulmonary adaptations provide protection from oedema formation, but whilst initially protective, are also likely to confer major long-term disadvantages in chronic heart failure.
- Subjects
HEART failure; HEART diseases; HEART ventricles; CHEST (Anatomy); HYPERTENSION; ANTHROPOMETRY; BODY weight
- Publication
Basic Research in Cardiology, 2003, Vol 98, Issue 5, p295
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s00395-003-0419-6