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- Title
Developing tools for defining and establishing pathways of toxicity.
- Authors
Andersen, Melvin; McMullen, Patrick; Krewski, Daniel
- Abstract
The article offers the author's perspective on the approaches for toxicity testing, highlighting the report from the U.S. National Research Council titled "Toxicity Testing in the 21st Century." The report envisioned a shift in testing away from studies of apical endpoints in test animals to the use of human cells to evaluate perturbations of toxicity pathways (TPs). According to the author, the report has produced subsequent discussion.
- Subjects
TOXICITY testing; NATIONAL Research Council (U.S.); ANIMAL experimentation; QUANTUM perturbations; RESEARCH
- Publication
Archives of Toxicology, 2015, Vol 89, Issue 5, p809
- ISSN
0340-5761
- Publication type
Editorial
- DOI
10.1007/s00204-015-1512-y