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- Title
Effects of Eplerenone, a Selective Aldosterone Blocker, on the Progression of Left Ventricular Dysfunction and Remodeling in Rats with Dilated Cardiomyopathy.
- Authors
Wahed, Mir Imam Ibne; Watanabe, Kenichi; Ma, Meilei; Yamaguchi, Kenichi; Takahashi, Toshihiro; Tachikawa, Hitoshi; Kodama, Makoto; Aizawa, Yushifusa
- Abstract
Aldosterone blockade reduces morbidity and mortality in patients with heart failure. We studied the effects of eplerenone, a novel aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy after autoimmune myocarditis. Twenty-eight days after immunization, the surviving Lewis rats were randomized to 1 month’s oral treatment with low-dose eplerenone (group L), high-dose eplerenone (group H) or vehicle (group V). Five of 15 (33%) rats in group V and 3 of 15 (20%) rats in group L died during the course of treatment. High-dose eplerenone significantly reduced cardiomyocyte hypertrophy, heart weight and heart weight to body weight ratio. Eplerenone improved left ventricular function in a dose-dependent manner. Central venous pressure and left ventricular end-diastolic pressure were lower, and ±dP/dt and fractional shortening were higher in group H than group V. Eplerenone also attenuated myocardial fibrosis and reduced left ventricular mRNA expressions of TGF-β1 and collagen-III. Our results indicate that treatment with eplerenone improved left ventricular dysfunction and attenuated left ventricular remodeling in rats with heart failure. Copyright © 2005 S. Karger AG, Basel
- Subjects
CARDIOMYOPATHIES; ALDOSTERONE; MINERALOCORTICOIDS; RATS; LEFT heart ventricle; MYOCARDITIS
- Publication
Pharmacology, 2005, Vol 73, Issue 2, p81
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000081267