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- Title
Increased Incidence of Thyroid Disease in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis.
- Authors
Xin, Caihong; Sun, Xin; Lu, Li; Yang, Rong; Shan, Ling; Wang, Yang
- Abstract
<bold>Background: </bold>Alopecia areata (AA) is a common, clinically heterogeneous, immune-mediated, nonscarring hair loss disease with a pathogenesis that is not fully understood. The prevalence of thyroid disease is likely increased among individuals with AA. However, this association remains controversial.<bold>Objective: </bold>To evaluate the risk of thyroid disease in patients with AA.<bold>Methods: </bold>We performed a systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and AA.<bold>Results: </bold>In total, 17 articles were included in this meta-analysis, with 2,850 AA cases and 4,667 controls. Overall, the prevalence of thyroid disease in patients with AA was significantly increased compared with that in controls (odds ratios 3.66, 95% confidence intervals 2.90-4.61).<bold>Conclusions: </bold>The results suggest that AA patients should be screened for thyroid disease.
- Subjects
THYROID diseases; ALOPECIA areata; DISEASE incidence; HAIR diseases; PATHOLOGY; RELATIVE medical risk; RESEARCH; META-analysis; RESEARCH methodology; SYSTEMATIC reviews; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; DISEASE prevalence
- Publication
Dermatology (10188665), 2020, Vol 236, Issue 3, p251
- ISSN
1018-8665
- Publication type
meta analysis
- DOI
10.1159/000502025