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- Title
Three-component condensation of 1,3-dimethyl-barbituric acid, arylglyoxals, and substituted thioureas.
- Authors
Kolos, N.; Zamigailo, L.; Chechina, N.; Omel'chenko, I.; Shishkin, O.; Vashchenko, E.
- Abstract
4-Aryl-2-methylaminothiazoles and 5-aryl-2-mercapto-1-methylimidazoles, containing a fragment of 1,3-dimethylbarbituric acid, have been synthesized by the one-pot three-component condensation of 1,3-dimethylbarbituric acid, arylglyoxal hydrates, and N-methylthiourea. The analogous reaction involving N-arylthioureas proceeds regioselectively with the formation of 4-aryl-2-arylaminothiazoles. It was established that in the crystalline state 5-aryl-2-mercaptoimidazoles exist in the imidazoline-2-thione form.
- Subjects
THIAZOLES; RING formation (Chemistry); CONDENSATION; IMIDAZOLINES; THIONES; CHEMICAL derivatives
- Publication
Chemistry of Heterocyclic Compounds, 2013, Vol 48, Issue 12, p1817
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-013-1214-4