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- Title
Elective single day 3 embryo transfer halves the twinning rate without decrease in the ongoing pregnancy rate of an IVF/ICSI programme.
- Authors
Gerris, Jan; De Neubourg, Diane; Mangelschots, Katelijne; Van Royen, Eric; Vercruyssen, Miet; Barudy-Vasquez, Jorge; Valkenburg, Marion; Ryckaert, Greet
- Abstract
<bold>Background: </bold>Data on the effect of elective single embryo transfer (eSET) on the total and multiple pregnancy rates of an IVF/ICSI programme are reported.<bold>Methods and Results: </bold>A retrospective cohort analysis of eSET was carried out over a 4 year period. A total of 1559 cycles resulted in 1464 transfers; 299 transfers of one top quality embryo (20.4%) and 86 of one non-top quality embryo (5.9%) yielded 149 conceptions (49.8%) with 105 ongoing pregnancies (35.1%) and 26 conceptions (30.2%) with 19 ongoing implantations (22.1%) respectively; 1079 transfers of two (n = 853; 58.3%) or more than two (n = 226; 15.4%) embryos yielded 366 ongoing pregnancies (33.9%). The ongoing pregnancy rates for the years between 1998 and 2001 were 35.9, 27.9, 31.9 and 31.0% per oocyte retrieval and 38.5, 29.4, 34.1 and 33.2% per transfer. There were no differences in pregnancy rates between any of the years. The average ongoing pregnancy rate (>12 weeks) over the 4 years was 31.5% per started cycle and 33.5% per transfer; the average number of embryos transferred decreased from 2.26 (1998) to 1.79 (2001); the multiple pregnancy and twinning rates dropped from 33.6 and 29.5% (1998) to 18.6 and 16.3% (2001) respectively.<bold>Conclusions: </bold>Judicious application of eSET can halve the twinning rate while maintaining the overall pregnancy rate.
- Publication
Human Reproduction, 2002, Vol 17, Issue 10, p2626
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/17.10.2626