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- Title
Cryoprotection of human oocytes: inappropriate exposure to DMSO reduces fertilization rates.
- Authors
Pickering, Susan J.; Braude, Peter R.; Johnson, Martin H.; Pickering, S J; Braude, P R; Johnson, M H
- Abstract
Human oocytes were exposed to the cryoprotectant dimethyl-sulphoxide (DMSO) at either 4 or 37 degrees C. Subsequent fertilization of these oocytes showed that exposure to DMSO at 37 degrees C was associated with a greatly reduced fertilization rate when compared to untreated control oocytes, whereas no such reduction was seen in oocytes exposed to DMSO at 4 degrees C. The significance of these results for the potential cryopreservation of human oocytes is discussed.
- Publication
Human Reproduction, 1991, Vol 6, Issue 1, p142
- ISSN
0268-1161
- Publication type
journal article