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- Title
Activity-based protein profiling for biochemical pathway discovery in cancer.
- Authors
Nomura, Daniel K.; Dix, Melissa M.; Cravatt, Benjamin F.
- Abstract
Large-scale profiling methods have uncovered numerous gene and protein expression changes that correlate with tumorigenesis. However, determining the relevance of these expression changes and which biochemical pathways they affect has been hindered by our incomplete understanding of the proteome and its myriad functions and modes of regulation. Activity-based profiling platforms enable both the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumour cells. When integrated with other large-scale profiling methods, activity-based proteomics can provide insight into the metabolic and signalling pathways that support cancer pathogenesis and illuminate new strategies for disease diagnosis and treatment.
- Subjects
GENES; CARCINOGENESIS; CANCER research; BIOCHEMICAL genetics; PROTEOMICS; CHEMICAL biology; CANCER treatment; TUMOR diagnosis; TUMOR treatment; ANIMAL experimentation; BIOCHEMISTRY; CELLULAR signal transduction; COMPARATIVE studies; PHENOMENOLOGY; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TUMORS; EVALUATION research
- Publication
Nature Reviews Cancer, 2010, Vol 10, Issue 9, p630
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc2901