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- Title
An oxygen sensitive self-decision making engineered CAR T-cell.
- Authors
Juillerat, Alexandre; Marechal, Alan; Filhol, Jean Marie; Valogne, Yannick; Valton, Julien; Duclert, Aymeric; Duchateau, Philippe; Poirot, Laurent
- Abstract
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choice of targetable antigens. By fusing an oxygen sensitive subdomain of HIF1α to a CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of certain tumors. Along with the development of oxygen-sensitive CAR T-cells, this work also provides a basic framework to use a multi-chain CAR as a platform to create the next generation of smarter self-decision making CAR T-cells.
- Publication
Scientific Reports, 2017, p39833
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep39833