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- Title
Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes.
- Authors
Zatterale, Federica; Raciti, Gregory Alexander; Prevenzano, Immacolata; Leone, Alessia; Campitelli, Michele; De Rosa, Veronica; Beguinot, Francesco; Parrillo, Luca
- Abstract
For the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has continued to rise on a global level. The risk contributing to this pandemic implicates both genetic and environmental factors, which are functionally integrated by epigenetic mechanisms. While these conditions are accompanied by major abnormalities in fuel metabolism, evidence indicates that altered immune cell functions also play an important role in shaping of obesity and T2D phenotypes. Interestingly, these events have been shown to be determined by epigenetic mechanisms. Consistently, recent epigenome-wide association studies have demonstrated that immune cells from obese and T2D individuals feature specific epigenetic profiles when compared to those from healthy subjects. In this work, we have reviewed recent literature reporting epigenetic changes affecting the immune cell phenotype and function in obesity and T2D. We will further discuss therapeutic strategies targeting epigenetic marks for treating obesity and T2D-associated inflammation.
- Subjects
TYPE 2 diabetes; INFLAMMATION; EPIGENETICS; OBESITY; CELL physiology
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 7, pN.PAG
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12070982