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- Title
Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.
- Authors
Schauer, Grant; Leuba, Sanford; Sluis-Cremer, Nicolas
- Abstract
HIV-1 reverse transcriptase (RT) plays a central role in HIV infection. Current United States Federal Drug Administration (USFDA)-approved antiretroviral therapies can include one of five approved non-nucleoside RT inhibitors (NNRTIs), which are potent inhibitors of RT activity. Despite their crucial clinical role in treating and preventing HIV-1 infection, their mechanism of action remains elusive. In this review, we introduce RT and highlight major advances from experimental and computational biophysical experiments toward an understanding of RT function and the inhibitory mechanism(s) of NNRTIs.
- Subjects
NUCLEOSIDES; REVERSE transcriptase inhibitors; UNITED States. Food &; Drug Administration; HIV; HIV infections; BIOPHYSICS
- Publication
Biomolecules (2218-273X), 2013, Vol 3, Issue 4, p889
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom3040889