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- Title
Natural T-cell responses against minor histocompatibility antigen (mHag) HY following HLA-matched hematopoietic cell transplantation: what are the requirements for a ‘good’ mHag?
- Authors
Kollgaard, T.; Hadrup, S. Reker; Petersen, S. L.; Masmas, T. N.; Andersen, M. H.; Spierings, E.; Vindeløv, L.; thor Straten, P.
- Abstract
The article discusses the role of allogeneic hematopoietic cell transplantation (HCT) in treating hematologic malignancies. It says that HCT represents a potentially curative treatment for several hematologic malignancies. Meanwhile, the curative principle in allogeneic HCT with NMA conditioning is solely related to the graft-versus-leukemia (GVL) effect, and several lines of evidence strongly suggest that donor T cells are the main effectors.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; BLOOD diseases; LEUKEMIA; LYMPHOCYTES; HISTOCOMPATIBILITY antigens; T cells
- Publication
Leukemia (08876924), 2008, Vol 22, Issue 10, p1948
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2008.75