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- Title
Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.
- Authors
Iwamura, Chiaki; Kimura, Motoko Y.; Shinoda, Kenta; Endo, Yusuke; Hasegawa, Akihiro; Yamashita, Masakatsu; Nakayama, Toshinori
- Abstract
Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2−/−) CD4 T cells, the activation of nuclear factor-κB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we extend our investigation and demonstrate that Shn-2 regulates Th2 responses in vivo using an ovalbumin-induced allergic asthma model. Eosinophilic inflammation, mucus hyperproduction and airway hyperresponsiveness (AHR) were all enhanced in Shn-2−/− mice. Moreover, eosinophilic infiltration and AHR were enhanced in mice given a transfer of Shn-2−/− effector Th2. Shn-2 in Th2 is thus considered to play an important role as a negative regulator in allergic airway inflammation.
- Subjects
RESPIRATORY allergy; T cells; MICE; LYMPHOCYTES; MICROBIAL genetics; ASTHMA
- Publication
International Immunology, 2007, Vol 19, Issue 6, p755
- ISSN
0953-8178
- Publication type
Article
- DOI
10.1093/intimm/dxm042